Age modulates the link between stress-related neural activity and mortality

Nidaa Mikail, Noemi Sablonier, Pimrapat Gebert, Isabelle Glarner, Adriana Vinzens, Achi Haider, Atanas Todorov, Susan Bengs, Angela Portmann, Valerie Treyer, Susanne Wegener, Christoph Gräni, Aju P. Pazhenkottil, Caroline E. Gebhard, Vera Regitz-Zagrosek, Felix C. Tanner, Philipp A. Kaufmann, Ronny R. Buechel, Alexia Rossi and Catherine Gebhard ()
Additional contact information
Nidaa Mikail: University Hospital Zurich
Noemi Sablonier: University Hospital Zurich
Pimrapat Gebert: University Hospital Zurich
Isabelle Glarner: University Hospital Zurich
Adriana Vinzens: University Hospital Zurich
Achi Haider: University Hospital Zurich
Atanas Todorov: University Hospital Zurich
Susan Bengs: University Hospital Zurich
Angela Portmann: University Hospital Zurich
Valerie Treyer: University Hospital Zurich
Susanne Wegener: University of Zurich
Christoph Gräni: University of Bern
Aju P. Pazhenkottil: University Hospital Zurich
Caroline E. Gebhard: University of Basel
Vera Regitz-Zagrosek: Charité - Universitätsmedizin Berlin
Felix C. Tanner: University of Zurich
Philipp A. Kaufmann: University Hospital Zurich
Ronny R. Buechel: University Hospital Zurich
Alexia Rossi: University Hospital Zurich
Catherine Gebhard: University Hospital Zurich

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract Stress-related neural activity (SNA), as measured by amygdala metabolism, has been linked in prior work to all-cause mortality and major adverse cardiovascular events. In this study, we sought to clarify SNA determinants and test whether age modifies its association with all-cause mortality. Using 2-[18 F]fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET), we quantified amygdala metabolism, a surrogate for SNA, in 1,336 patients (mean age 59.4 ± 15.6 years, 37.8% women). Assessing demographic and imaging confounders, associations between SNA and mortality were evaluated in a subgroup of 960 participants with a median 5-year follow-up (IQR 3–9). Higher SNA appears independently associated with greater all-cause mortality across all age groups (HR 1.45, 95% CI 1.08-1.95; p = 0.012). The association is strongest in younger, healthier individuals (HR 7.86, 95% CI 2.92-21.21; p

Date: 2025
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DOI: 10.1038/s41467-025-64802-3

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