Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs

Nabil Haidour, Hugues Favre, Philippe Mateo, Juliette Reydet, Alain Bizé, Lucien Sambin, Jianping Dai, Paul-Matthieu Chiaroni, Bijan Ghaleh, Mathieu Pernot, Mickael Tanter and Clement Papadacci ()
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Nabil Haidour: CNRS
Hugues Favre: CNRS
Philippe Mateo: CNRS
Juliette Reydet: CNRS
Alain Bizé: National Veterinary School of Alfort
Lucien Sambin: National Veterinary School of Alfort
Jianping Dai: National Veterinary School of Alfort
Paul-Matthieu Chiaroni: National Veterinary School of Alfort
Bijan Ghaleh: National Veterinary School of Alfort
Mathieu Pernot: CNRS
Mickael Tanter: CNRS
Clement Papadacci: CNRS

Nature Communications, 2025, vol. 16, issue 1, 1-16

Abstract: Abstract Mapping microcirculation at the whole-organ scale in 3D is crucial for understanding vascular pathologies and improving diagnostics. Although 3D ultrasound localization microscopy (ULM) enables microscopic resolution by localizing intravenously injected microbubbles in small animal models, visualizing entire organs in large animals or humans remains challenging due to limited field of view, low sensitivity, and probe technological complexity. Here, we demonstrate how a multi-lens array method overcomes these limitations. Combined with 3D ULM, it maps and quantifies large vascular volumes (up to 120 × 100 × 82 mm³) at high spatial resolution (125–200 µm) with a volumetric acquisition rate of 312 Hz, using low-cost technology. This approach enables deeper insights into hemodynamics from large vessels to pre-capillary arterioles, by providing vast and rich datasets of whole-organ vascularization. It could also facilitate diagnosis of microcirculation disorders and monitoring of small-vessel disease treatments by addressing key limitations of current imaging modalities.

Date: 2025
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DOI: 10.1038/s41467-025-64911-z

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