Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults

Maggie A. Stanislawski (), Elizabeth Litkowski, Christopher H. Arehart, Kai Luo, Niles Gilmore, Leslie A. Lange, Ethan M. Lange, Kathleen Barnes, Christy L. Avery, Katie A. Meyer, Fernando Holguin, Kari E. North, Robert D. Burk and Robert C. Kaplan
Additional contact information
Maggie A. Stanislawski: University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine
Elizabeth Litkowski: University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine
Christopher H. Arehart: University of Colorado, Interdisciplinary Quantitative Biology Program
Kai Luo: Albert Einstein College of Medicine, Department of Epidemiology and Population Health
Niles Gilmore: University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine
Leslie A. Lange: University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine
Ethan M. Lange: University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine
Kathleen Barnes: University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine
Christy L. Avery: University of North Carolina, Department of Epidemiology, Gillings School of Global Public Health
Katie A. Meyer: University of North Carolina, Department of Nutrition, Gillings School of Global Public Health
Fernando Holguin: University of Colorado Anschutz, Department of Medicine, School of Medicine
Kari E. North: The University of Texas Health Science Center, Epidemiology, School of Public Health
Robert D. Burk: Albert Einstein College of Medicine, Department of Epidemiology and Population Health
Robert C. Kaplan: Albert Einstein College of Medicine, Department of Epidemiology and Population Health

Nature Communications, 2025, vol. 16, issue 1, 1-12

Abstract: Abstract Asthma is a heterogeneous condition that is often comorbid with obesity and influenced by diverse risk factors. Elucidating the association of gut microbial characteristics with asthma could improve our understanding of the pathophysiology. Here, we investigate relationships of host genetics and stool microbiota characteristics with asthma among US Hispanic/Latino adults, while considering the influence of obesity status, using host whole genome sequencing and stool shotgun metagenomic microbiota data from participants of the Hispanic Community Health Study/Study of Latinos. We evaluate cross-sectional associations of microbiota characteristics with asthma and analyse whether they are modified by obesity status (body mass index≥30 kg/m2). We assess differences in alpha diversity, beta diversity, and taxonomic abundance with asthma, independent of obesity, and interactions between asthma and obesity using covariate-adjusted regression-based methods. We generate an asthma polygenic risk score (PRS) and compare the classification accuracy of genetic and microbial factors for asthma status. We report that asthma is associated with differences in overall taxonomic composition (beta diversity; p = 0.001), which is not dependent on obesity status (p = 0.31). Asthma is not associated with alpha diversity metrics (p > 0.17), though obesity is associated with lower alpha diversity (p

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-65028-z Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-65028-z

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-65028-z

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().