Cross-regional real-time visualization of systemic physiology and dynamics with 3D panoramic photoacoustic computed tomography (3D-PanoPACT)

Xuanhao Wang, Yuqian Meng, Mingli Sun, Xiali Gao, Yuqi Wang, Shaobo Wang, Kaiyue Wang, Ruofan Wang, Danyang Ren, Yonggang Yin, Chiye Li, Ruimin Chen, Lihong V. Wang () and Junhui Shi ()
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Xuanhao Wang: Zhejiang Lab
Yuqian Meng: Zhejiang Lab
Mingli Sun: Zhejiang Lab
Xiali Gao: Zhejiang Lab
Yuqi Wang: Zhejiang Lab
Shaobo Wang: Zhejiang Lab
Kaiyue Wang: Zhejiang Lab
Ruofan Wang: Zhejiang Lab
Danyang Ren: Zhejiang Lab
Yonggang Yin: Zhejiang Lab
Chiye Li: Zhejiang Lab
Ruimin Chen: Zhejiang Lab
Lihong V. Wang: California Institute of Technology
Junhui Shi: Zhejiang Lab

Nature Communications, 2025, vol. 16, issue 1, 1-23

Abstract: Abstract Non-invasive systemic visualization is crucial in biomedical research. Photoacoustic imaging transcends the optical scattering limitations, capturing optical absorption from deep tissue at high resolution. Nevertheless, the full exploitation of its physical advantages faces challenges due to unsatisfactory field of view (FOV), spatiotemporal resolution, and imaging quality. Here, we demonstrate that 3D panoramic photoacoustic computed tomography (3D-PanoPACT) mitigates these limitations by combining dynamical and functional contrasts, high spatiotemporal resolution, and broad three-dimensional FOV, allowing for visualizing cross-regional dynamics from organ to whole-body level. Leveraging its single-pulse-volumetric imaging capability, 3D-PanoPACT imaged the whole liver at 25 Hz, facilitating the extraction of arterial networks. Real-time monitoring of whole-brain vasculatures and functional hemodynamics induced by pharmacological action and physical stimulation was demonstrated, especially in the Circle of Willis. The dynamic visualization of the whole trunk at 10 Hz further substantiates its capacity for systemic imaging. We tracked the metabolic pathways of a small-molecule probe across multiple organs using 3D-PanoPACT, highlighting its value in whole-body, cross-regional dynamic studies. 3D-PanoPACT, being a potent novel imaging tool, exhibits substantial potential for advancing biotechnology.

Date: 2025
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DOI: 10.1038/s41467-025-65054-x

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