Psilocybin alters visual contextual computations

Marco Aqil (), Gilles de Hollander, Nina Vreugdenhil, Tomas Knapen and Serge O. Dumoulin
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Marco Aqil: Spinoza Centre for Neuroimaging
Gilles de Hollander: University of Zurich, Zurich Center for Neuroeconomics, Department of Economics
Nina Vreugdenhil: Spinoza Centre for Neuroimaging
Tomas Knapen: Spinoza Centre for Neuroimaging
Serge O. Dumoulin: Spinoza Centre for Neuroimaging

Nature Communications, 2025, vol. 16, issue 1, 1-10

Abstract: Abstract Psilocybin alters perception and brain dynamics. Here, we investigate the effects of psilocybin using psychophysics, ultra-high field functional MRI, and computational modeling. We find that psilocybin alters contextual perception in the Ebbinghaus illusion, as well as contextual modulation in cortical responses to visual stimuli. We propose a computational model capable of capturing and linking these changes. Leveraging vision as a beachhead, our findings highlight the alteration of contextual computations as a potential general mechanism underlying psychedelic action.

Date: 2025
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DOI: 10.1038/s41467-025-65150-y

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