A systematic review and meta-analysis of the impact of vaccination on prevention of long COVID

Rhiannon Green, Zoe Marjenberg, Gregory Y. H. Lip, Amitava Banerjee, Juan Wisnivesky, Brendan C. Delaney, Michael J. Peluso, Elke Wynberg and Sultan Abduljawad ()
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Rhiannon Green: Maverex Ltd
Zoe Marjenberg: Maverex Ltd
Gregory Y. H. Lip: Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool Centre for Cardiovascular Science at University of Liverpool
Amitava Banerjee: University College London, Institute of Health Informatics
Juan Wisnivesky: Icahn School of Medicine at Mount Sinai, Division of General Internal Medicine
Brendan C. Delaney: Imperial College London, Department of Surgery and Cancer
Michael J. Peluso: San Francisco, Division of HIV, Infectious Diseases, and Global Medicine, University of California
Elke Wynberg: Mahidol University, Mahidol-Oxford Tropical Medicine Research Unit (MORU)
Sultan Abduljawad: BioNTech UK Ltd.

Nature Communications, 2025, vol. 16, issue 1, 1-11

Abstract: Abstract Long COVID affects millions worldwide and its prevention is a critical public health strategy. While prior analyses show primary vaccination prevents long COVID in subsequent infections, the effect of booster vaccination on long COVID after Omicron infections is unclear. This systematic review identifies 31 observational studies, of which 11 are suitable for pairwise meta-analyses. The pooled odds ratio (OR) of long COVID in those vaccinated (any dose) versus unvaccinated is 0.77 (95% confidence interval [CI] 0.70–0.85; p

Date: 2025
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DOI: 10.1038/s41467-025-65302-0

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