Multifunctional nanoparticles as coupled contrast agents

Yongdong Jin, Congxian Jia, Sheng-Wen Huang, Matthew O'Donnell () and Xiaohu Gao ()
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Yongdong Jin: University of Washington, William H Foege Building N530M, Seattle, Washington 98195, USA.
Congxian Jia: University of Michigan
Sheng-Wen Huang: University of Washington, William H Foege Building N530M, Seattle, Washington 98195, USA.
Matthew O'Donnell: University of Washington, William H Foege Building N530M, Seattle, Washington 98195, USA.
Xiaohu Gao: University of Washington, William H Foege Building N530M, Seattle, Washington 98195, USA.

Nature Communications, 2010, vol. 1, issue 1, 1-8

Abstract: Abstract Engineering compact imaging probes with highly integrated modalities is a key focus in bionanotechnology and will have profound impact on molecular diagnostics, imaging and therapeutics. However, combining multiple components on a nanometre scale to create new imaging modalities unavailable from individual components has proven to be challenging. In this paper, we demonstrate iron oxide and gold-coupled core-shell nanoparticles (NPs) with well-defined structural characteristics (for example, size, shell thickness and core-shell separation) and physical properties (for example, electronic, magnetic, optical, thermal and acoustic). The resulting multifunctional nanoprobes not only offer contrast for electron microscopy, magnetic resonance imaging and scattering-based imaging but, more importantly, enable a new imaging mode, magnetomotive photoacoustic imaging, with remarkable contrast enhancement compared with photoacoustic images using conventional NP contrast agents.

Date: 2010
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DOI: 10.1038/ncomms1042

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