Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

Warren R.J.D. Galloway, Albert Isidro-Llobet and David R. Spring ()
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Warren R.J.D. Galloway: The University Chemical Laboratory, University of Cambridge
Albert Isidro-Llobet: The University Chemical Laboratory, University of Cambridge
David R. Spring: The University Chemical Laboratory, University of Cambridge

Nature Communications, 2010, vol. 1, issue 1, 1-13

Abstract: Biologically active molecules can be identified through the screening of small-molecule libraries, but compound collections typically consist of large numbers of structurally similar compounds. Gallowayet al. review how diversity-oriented synthesis can efficiently generate structurally diverse compound libraries.

Date: 2010
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DOI: 10.1038/ncomms1081

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