Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions

Christof Grüring, Arlett Heiber, Florian Kruse, Johanna Ungefehr, Tim-Wolf Gilberger () and Tobias Spielmann ()
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Christof Grüring: Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Street 74
Arlett Heiber: Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Street 74
Florian Kruse: Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Street 74
Johanna Ungefehr: Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Street 74
Tim-Wolf Gilberger: Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Street 74
Tobias Spielmann: Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Street 74

Nature Communications, 2011, vol. 2, issue 1, 1-11

Abstract: Abstract Blood stages of Plasmodium falciparum cause the pathology of malaria; however, the progression of the parasite through this complex part of the life cycle has never been visualized. In this study, we use four-dimensional imaging to show for the first time the development of individual parasites in erythrocytes and the concomitant host cell modifications. Our data visualize an unexpectedly dynamic parasite, provide a reference for this life cycle stage and challenge the model that protein export in P. falciparum is linked to the biogenesis of host cell modifications termed Maurer's clefts. Our results provide a novel view of the blood-stage development, Maurer's cleft development and protein export in malaria parasites, and open the door to study dynamic processes, drug effects and the phenotype of mutants.

Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1169

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DOI: 10.1038/ncomms1169

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