Parallel evolution of the make–accumulate–consume strategy in Saccharomyces and Dekkera yeasts

Elżbieta Rozpędowska, Linda Hellborg, Olena P. Ishchuk, Furkan Orhan, Silvia Galafassi, Annamaria Merico, Megan Woolfit, Concetta Compagno and Jure Piškur ()
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Elżbieta Rozpędowska: Lund University
Linda Hellborg: Lund University
Olena P. Ishchuk: Lund University
Furkan Orhan: Lund University
Silvia Galafassi: Università degli Studi di Milano
Annamaria Merico: Università degli Studi di Milano
Megan Woolfit: Smurfit Institute, Trinity College Dublin
Concetta Compagno: Università degli Studi di Milano
Jure Piškur: Lund University

Nature Communications, 2011, vol. 2, issue 1, 1-7

Abstract: Abstract Saccharomyces yeasts degrade sugars to two-carbon components, in particular ethanol, even in the presence of excess oxygen. This characteristic is called the Crabtree effect and is the background for the 'make–accumulate–consume' life strategy, which in natural habitats helps Saccharomyces yeasts to out-compete other microorganisms. A global promoter rewiring in the Saccharomyces cerevisiae lineage, which occurred around 100 mya, was one of the main molecular events providing the background for evolution of this strategy. Here we show that the Dekkera bruxellensis lineage, which separated from the Saccharomyces yeasts more than 200 mya, also efficiently makes, accumulates and consumes ethanol and acetic acid. Analysis of promoter sequences indicates that both lineages independently underwent a massive loss of a specific cis-regulatory element from dozens of genes associated with respiration, and we show that also in D. bruxellensis this promoter rewiring contributes to the observed Crabtree effect.

Date: 2011
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DOI: 10.1038/ncomms1305

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