The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans

Wei Li, Lijun Kang, Beverly J. Piggott, Zhaoyang Feng and X.Z. Shawn Xu ()
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Wei Li: Life Sciences Institute, University of Michigan
Lijun Kang: Life Sciences Institute, University of Michigan
Beverly J. Piggott: Life Sciences Institute, University of Michigan
Zhaoyang Feng: Life Sciences Institute, University of Michigan
X.Z. Shawn Xu: Life Sciences Institute, University of Michigan

Nature Communications, 2011, vol. 2, issue 1, 1-9

Abstract: Abstract Most animals can distinguish two distinct types of touch stimuli: gentle (innocuous) and harsh (noxious/painful) touch, however, the underlying mechanisms are not well understood. Caenorhabditis elegans is a useful model for the study of gentle touch sensation. However, little is known about harsh touch sensation in this organism. Here we characterize harsh touch sensation in C. elegans. We show that C. elegans exhibits differential behavioural responses to harsh touch and gentle touch. Laser ablations identify distinct sets of sensory neurons and interneurons required for harsh touch sensation at different body segments. Optogenetic stimulation of the circuitry can drive behaviour. Patch-clamp recordings reveal that TRP family and amiloride-sensitive Na+ channels mediate touch-evoked currents in different sensory neurons. Our work identifies the neural circuits and characterizes the sensory channels mediating harsh touch sensation in C. elegans, establishing it as a genetic model for studying this sensory modality.

Date: 2011
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DOI: 10.1038/ncomms1308

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