Blimp1 regulates the transition of neonatal to adult intestinal epithelium

Vanesa Muncan, Jarom Heijmans, Stephen D. Krasinski, Nikè V. Büller, Manon E. Wildenberg, Sander Meisner, Marijana Radonjic, Kelly A. Stapleton, Wout H. Lamers, Izak Biemond, Marius A. van den Bergh Weerman, Dónal O'Carroll, James C. Hardwick, Daniel W. Hommes and Gijs R. van den Brink ()
Additional contact information
Vanesa Muncan: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Jarom Heijmans: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Stephen D. Krasinski: Children's Hospital Boston
Nikè V. Büller: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Manon E. Wildenberg: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Sander Meisner: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Marijana Radonjic: Nutrigenomic Consortium, Top Institute Food and Nutrition
Kelly A. Stapleton: Children's Hospital Boston
Wout H. Lamers: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Izak Biemond: Leiden University Medical Center
Marius A. van den Bergh Weerman: Academic Medical Center
Dónal O'Carroll: EMBL Monterotondo Mouse Biology Unit
James C. Hardwick: Leiden University Medical Center
Daniel W. Hommes: Leiden University Medical Center
Gijs R. van den Brink: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center

Nature Communications, 2011, vol. 2, issue 1, 1-9

Abstract: Abstract In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental changes are the result of a genetic programme intrinsic to the gut tube, but its regulators have not been identified. Here we show that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition. Intestine-specific deletion of Blimp1 results in growth retardation and excessive neonatal mortality. Mutant mice lack all of the typical epithelial features of the suckling period and are born with features of an adult-like intestine. We conclude that the suckling to weaning transition is regulated by a single transcriptional repressor that delays epithelial maturation.

Date: 2011
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DOI: 10.1038/ncomms1463

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