The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke

Kazuhiko Nakano, Kazuya Hokamura, Naho Taniguchi, Koichiro Wada (), Chiho Kudo, Ryota Nomura, Ayuchi Kojima, Shuhei Naka, Yoshinori Muranaka, Min Thura, Atsushi Nakajima, Katsuhiko Masuda, Ichiro Nakagawa, Pietro Speziale, Nobumitsu Shimada, Atsuo Amano, Yoshinori Kamisaki, Tokutaro Tanaka, Kazuo Umemura and Takashi Ooshima
Additional contact information
Kazuhiko Nakano: Graduate School of Dentistry, Osaka University
Kazuya Hokamura: Hamamatsu University School of Medicine
Naho Taniguchi: Graduate School of Dentistry, Osaka University
Koichiro Wada: Graduate School of Dentistry, Osaka University
Chiho Kudo: Graduate School of Dentistry, Osaka University
Ryota Nomura: Graduate School of Dentistry, Osaka University
Ayuchi Kojima: Graduate School of Dentistry, Osaka University
Shuhei Naka: Graduate School of Dentistry, Osaka University
Yoshinori Muranaka: Laboratory for Ultrastructure Researches, Hamamatsu University School of Medicine
Min Thura: Hamamatsu University School of Medicine
Atsushi Nakajima: Yokohama City University School of Medicine
Katsuhiko Masuda: Graduate School of Dentistry, Osaka University
Ichiro Nakagawa: Section of Bacterial Pathogenesis, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Pietro Speziale: University of Pavia
Nobumitsu Shimada: Suita Municipal Hospital
Atsuo Amano: Graduate School of Dentistry, Osaka University
Yoshinori Kamisaki: Graduate School of Dentistry, Osaka University
Tokutaro Tanaka: Seirei Hamamatsu General Hospital
Kazuo Umemura: Hamamatsu University School of Medicine
Takashi Ooshima: Graduate School of Dentistry, Osaka University

Nature Communications, 2011, vol. 2, issue 1, 1-10

Abstract: Abstract Although several risk factors for stroke have been identified, one-third remain unexplained. Here we show that infection with Streptococcus mutans expressing collagen-binding protein (CBP) is a potential risk factor for haemorrhagic stroke. Infection with serotype k S. mutans, but not a standard strain, aggravates cerebral haemorrhage in mice. Serotype k S. mutans accumulates in the damaged, but not the contralateral hemisphere, indicating an interaction of bacteria with injured blood vessels. The most important factor for high-virulence is expression of CBP, which is a common property of most serotype k strains. The detection frequency of CBP-expressing S. mutans in haemorrhagic stroke patients is significantly higher than in control subjects. Strains isolated from haemorrhagic stroke patients aggravate haemorrhage in a mouse model, indicating that they are haemorrhagic stroke-associated. Administration of recombinant CBP causes aggravation of haemorrhage. Our data suggest that CBP of S. mutans is directly involved in haemorrhagic stroke.

Date: 2011
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DOI: 10.1038/ncomms1491

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