Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour
Andreas W. Ettinger,
Michaela Wilsch-Bräuninger,
Anne-Marie Marzesco,
Marc Bickle,
Annett Lohmann,
Zoltan Maliga,
Jana Karbanová,
Denis Corbeil,
Anthony A. Hyman and
Wieland B. Huttner ()
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Andreas W. Ettinger: Max Planck Institute of Molecular Cell Biology and Genetics
Michaela Wilsch-Bräuninger: Max Planck Institute of Molecular Cell Biology and Genetics
Anne-Marie Marzesco: Max Planck Institute of Molecular Cell Biology and Genetics
Marc Bickle: Max Planck Institute of Molecular Cell Biology and Genetics
Annett Lohmann: Max Planck Institute of Molecular Cell Biology and Genetics
Zoltan Maliga: Max Planck Institute of Molecular Cell Biology and Genetics
Jana Karbanová: BIOTEC, Technische Universität Dresden
Denis Corbeil: BIOTEC, Technische Universität Dresden
Anthony A. Hyman: Max Planck Institute of Molecular Cell Biology and Genetics
Wieland B. Huttner: Max Planck Institute of Molecular Cell Biology and Genetics
Nature Communications, 2011, vol. 2, issue 1, 1-12
Abstract:
Abstract The central portion of the midbody, a cytoplasmic bridge between nascent daughter cells at the end of cell division, has generally been thought to be retained by one of the daughter cells, but has, recently, also been shown to be released into the extracellular space. The significance of midbody-retention versus -release is unknown. Here we show, by quantitatively analysing midbody-fate in various cell lines under different growth conditions, that the extent of midbody-release is significantly greater in stem cells than cancer-derived cells. Induction of cell differentiation is accompanied by an increase in midbody-release. Knockdown of the endosomal sorting complex required for transport family members, Alix and tumour-suppressor gene 101, or of their interaction partner, centrosomal protein 55, impairs midbody-release, suggesting mechanistic similarities to abscission. Cells with such impaired midbody-release exhibit enhanced responsiveness to a differentiation stimulus. Taken together, midbody-release emerges as a characteristic feature of cells capable of differentiation.
Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1511
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DOI: 10.1038/ncomms1511
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