Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision

Mathias W. Seeliger (), Arne Brombas, Reto Weiler, Peter Humphries, Gabriel Knop, Naoyuki Tanimoto and Frank Müller ()
Additional contact information
Mathias W. Seeliger: Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University of Tübingen, Schleichstr. 4/3, D-72076 Tübingen, Germany.
Arne Brombas: Institute of Complex Systems, Cellular Biophysics (ICS-4), Forschungszentrum Jülich
Reto Weiler: Carl von Ossietzky University
Peter Humphries: Ocular Genetics Unit, Trinity College
Gabriel Knop: Institute of Complex Systems, Cellular Biophysics (ICS-4), Forschungszentrum Jülich
Naoyuki Tanimoto: Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University of Tübingen, Schleichstr. 4/3, D-72076 Tübingen, Germany.
Frank Müller: Institute of Complex Systems, Cellular Biophysics (ICS-4), Forschungszentrum Jülich

Nature Communications, 2011, vol. 2, issue 1, 1-10

Abstract: Abstract Retinal photoreceptors permit visual perception over a wide range of lighting conditions. Rods work best in dim, and cones in bright environments, with considerable functional overlap at intermediate (mesopic) light levels. At many sites in the outer and inner retina where rod and cone signals interact, gap junctions, particularly those containing Connexin36, have been identified. However, little is known about the dynamic processes associated with the convergence of rod and cone system signals into ON- and OFF-pathways. Here we show that proper cone vision under mesopic conditions requires rapid adaptational feedback modulation of rod output via hyperpolarization-activated and cyclic nucleotide-gated channels 1. When these channels are absent, sustained rod responses following bright light exposure saturate the retinal network, resulting in a loss of downstream cone signalling. By specific genetic and pharmacological ablation of key signal processing components, regular cone signalling can be restored, thereby identifying the sites involved in functional rod–cone interactions.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms1540 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1540

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms1540

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().