Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis

Hanshuo Zhang, Yang Hao, Junyu Yang, Ying Zhou, Juan Li, Shenyi Yin, Changhong Sun, Ming Ma, Yanyi Huang and Jianzhong Jeff Xi ()
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Hanshuo Zhang: College of Engineering, Peking University
Yang Hao: College of Engineering, Peking University
Junyu Yang: College of Engineering, Peking University
Ying Zhou: College of Engineering, Peking University
Juan Li: College of Engineering, Peking University
Shenyi Yin: College of Engineering, Peking University
Changhong Sun: College of Engineering, Peking University
Ming Ma: College of Engineering, Peking University
Yanyi Huang: College of Engineering, Peking University
Jianzhong Jeff Xi: College of Engineering, Peking University

Nature Communications, 2011, vol. 2, issue 1, 1-11

Abstract: Abstract miRNA globally deregulates human carcinoma. A critical open question is how many miRNAs functionally participate in cancer development, particularly in metastasis. We systematically evaluate the capability of all known human miRNAs to regulate certain metastasis-relevant cell behaviours. To perform the high-throughput screen of miRNAs, which regulate cell migration, we developed a novel self-assembled cell microarray. Here we show that over 20% of miRNAs have migratory regulation activity in diverse cell types, indicating a general involvement of miRNAs in migratory regulation. MiR-23b, which is downregulated in human colon cancer samples, potently mediates the multiple steps of metastasis, including tumour growth, invasion and angiogenesis in vivo. It regulates a cohort of prometastatic targets, including FZD7 or MAP3k1. These findings provide new insight into the physiological and potential therapeutic importance of miRNAs as a new class of functional modulators.

Date: 2011
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DOI: 10.1038/ncomms1555

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