Stochastic signalling rewires the interaction map of a multiple feedback network during yeast evolution

Chieh Hsu, Simone Scherrer, Antoine Buetti-Dinh, Prasuna Ratna, Julia Pizzolato, Vincent Jaquet and Attila Becskei ()
Additional contact information
Chieh Hsu: Biozentrum, University of Basel
Simone Scherrer: Institute of Molecular Life Sciences, University of Zurich
Antoine Buetti-Dinh: Institute of Molecular Life Sciences, University of Zurich
Prasuna Ratna: Institute of Molecular Life Sciences, University of Zurich
Julia Pizzolato: Institute of Molecular Life Sciences, University of Zurich
Vincent Jaquet: Biozentrum, University of Basel
Attila Becskei: Biozentrum, University of Basel

Nature Communications, 2012, vol. 3, issue 1, 1-10

Abstract: Abstract During evolution, genetic networks are rewired through strengthening or weakening their interactions to develop new regulatory schemes. In the galactose network, the GAL1/GAL3 paralogues and the GAL2 gene enhance their own expression mediated by the Gal4p transcriptional activator. The wiring strength in these feedback loops is set by the number of Gal4p binding sites. Here we show using synthetic circuits that multiplying the binding sites increases the expression of a gene under the direct control of an activator, but this enhancement is not fed back in the circuit. The feedback loops are rather activated by genes that have frequent stochastic bursts and fast RNA decay rates. In this way, rapid adaptation to galactose can be triggered even by weakly expressed genes. Our results indicate that nonlinear stochastic transcriptional responses enable feedback loops to function autonomously, or contrary to what is dictated by the strength of interactions enclosing the circuit.

Date: 2012
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms1687 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1687

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms1687

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().