Network physiology reveals relations between network topology and physiological function

Amir Bashan, Ronny P. Bartsch, Jan. W. Kantelhardt, Shlomo Havlin and Plamen Ch. Ivanov ()
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Amir Bashan: Bar-Ilan University
Ronny P. Bartsch: Brigham and Women's Hospital
Jan. W. Kantelhardt: Institute of Physics, Martin-Luther-Universität Halle-Wittenberg
Shlomo Havlin: Bar-Ilan University
Plamen Ch. Ivanov: Brigham and Women's Hospital

Nature Communications, 2012, vol. 3, issue 1, 1-9

Abstract: Abstract The human organism is an integrated network where complex physiological systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with different types of interactions is a challenge. Here we develop a framework to probe interactions among diverse systems, and we identify a physiological network. We find that each physiological state is characterized by a specific network structure, demonstrating a robust interplay between network topology and function. Across physiological states, the network undergoes topological transitions associated with fast reorganization of physiological interactions on time scales of a few minutes, indicating high network flexibility in response to perturbations. The proposed system-wide integrative approach may facilitate the development of a new field, Network Physiology.

Date: 2012
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DOI: 10.1038/ncomms1705

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