Intracellular chloride concentration influences the GABAA receptor subunit composition

Francesca Succol, Hubert Fiumelli, Fabio Benfenati, Laura Cancedda and Andrea Barberis ()
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Francesca Succol: The Italian Institute of Technology
Hubert Fiumelli: Center for Psychiatric Neurosciences, CHUV
Fabio Benfenati: The Italian Institute of Technology
Laura Cancedda: The Italian Institute of Technology
Andrea Barberis: The Italian Institute of Technology

Nature Communications, 2012, vol. 3, issue 1, 1-10

Abstract: Abstract GABAA receptors (GABAARs) exist as different subtype variants showing unique functional properties and defined spatio-temporal expression pattern. The molecular mechanisms underlying the developmental expression of different GABAAR are largely unknown. The intracellular concentration of chloride ([Cl−]i), the main ion permeating through GABAARs, also undergoes considerable changes during maturation, being higher at early neuronal stages with respect to adult neurons. Here we investigate the possibility that [Cl−]i could modulate the sequential expression of specific GABAARs subtypes in primary cerebellar neurons. We show that [Cl−]i regulates the expression of α3-1 and δ-containing GABAA receptors, responsible for phasic and tonic inhibition, respectively. Our findings highlight the role of [Cl−]i in tuning the strength of GABAergic responses by acting as an intracellular messenger.

Date: 2012
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DOI: 10.1038/ncomms1744

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