Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

Koh-ei Toyoshima, Kyosuke Asakawa, Naoko Ishibashi, Hiroshi Toki, Miho Ogawa, Tomoko Hasegawa, Tarou Irié, Tetsuhiko Tachikawa, Akio Sato, Akira Takeda and Takashi Tsuji ()
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Koh-ei Toyoshima: Research Institute for Science and Technology, Tokyo University of Science
Kyosuke Asakawa: Graduate School of Industrial Science and Technology, Tokyo University of Science
Naoko Ishibashi: Graduate School of Industrial Science and Technology, Tokyo University of Science
Hiroshi Toki: Research Institute for Science and Technology, Tokyo University of Science
Miho Ogawa: Organ Technologies Inc.
Tomoko Hasegawa: Graduate School of Industrial Science and Technology, Tokyo University of Science
Tarou Irié: Showa University School of Dentistry
Tetsuhiko Tachikawa: Showa University School of Dentistry
Akio Sato: Research Institute for Science and Technology, Tokyo University of Science
Akira Takeda: Research Institute for Science and Technology, Tokyo University of Science
Takashi Tsuji: Research Institute for Science and Technology, Tokyo University of Science

Nature Communications, 2012, vol. 3, issue 1, 1-12

Abstract: Abstract Organ replacement regenerative therapy is purported to enable the replacement of organs damaged by disease, injury or aging in the foreseeable future. Here we demonstrate fully functional hair organ regeneration via the intracutaneous transplantation of a bioengineered pelage and vibrissa follicle germ. The pelage and vibrissae are reconstituted with embryonic skin-derived cells and adult vibrissa stem cell region-derived cells, respectively. The bioengineered hair follicle develops the correct structures and forms proper connections with surrounding host tissues such as the epidermis, arrector pili muscle and nerve fibres. The bioengineered follicles also show restored hair cycles and piloerection through the rearrangement of follicular stem cells and their niches. This study thus reveals the potential applications of adult tissue-derived follicular stem cells as a bioengineered organ replacement therapy.

Date: 2012
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DOI: 10.1038/ncomms1784

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