Bats host major mammalian paramyxoviruses

Jan Felix Drexler, Victor Max Corman, Marcel Alexander Müller, Gael Darren Maganga, Peter Vallo, Tabea Binger, Florian Gloza-Rausch, Veronika M. Cottontail, Andrea Rasche, Stoian Yordanov, Antje Seebens, Mirjam Knörnschild, Samuel Oppong, Yaw Adu Sarkodie, Célestin Pongombo, Alexander N. Lukashev, Jonas Schmidt-Chanasit, Andreas Stöcker, Aroldo José Borges Carneiro, Stephanie Erbar, Andrea Maisner, Florian Fronhoffs, Reinhard Buettner, Elisabeth K. V. Kalko, Thomas Kruppa, Carlos Roberto Franke, René Kallies, Emmanuel R.N. Yandoko, Georg Herrler, Chantal Reusken, Alexandre Hassanin, Detlev H. Krüger, Sonja Matthee, Rainer G. Ulrich, Eric M. Leroy and Christian Drosten ()
Additional contact information
Jan Felix Drexler: Institute of Virology, University of Bonn Medical Centre
Victor Max Corman: Institute of Virology, University of Bonn Medical Centre
Marcel Alexander Müller: Institute of Virology, University of Bonn Medical Centre
Gael Darren Maganga: Centre International de Recherches Médicales de Franceville
Peter Vallo: Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, v.v.i.
Tabea Binger: Institute of Virology, University of Bonn Medical Centre
Florian Gloza-Rausch: Institute of Virology, University of Bonn Medical Centre
Veronika M. Cottontail: Institute of Experimental Ecology, University of Ulm
Andrea Rasche: Institute of Virology, University of Veterinary Medicine Hannover Foundation
Stoian Yordanov: Forestry Board Directorate of Strandja Natural Park
Antje Seebens: Noctalis, Centre for Bat Protection and Information
Mirjam Knörnschild: Institute of Experimental Ecology, University of Ulm
Samuel Oppong: Kwame Nkrumah University of Science and Technology
Yaw Adu Sarkodie: Kwame Nkrumah University of Science and Technology
Célestin Pongombo: University of Lubumbashi
Alexander N. Lukashev: Chumakov Institute of Poliomyelitis and Viral Encephalitides
Jonas Schmidt-Chanasit: Bernhard Nocht Institute for Tropical Medicine
Andreas Stöcker: Infectious Diseases Research Laboratory, University Hospital Professor Edgard Santos, Federal University of Bahia
Aroldo José Borges Carneiro: School of Veterinary Medicine, Federal University of Bahia
Stephanie Erbar: Institute of Virology, Philipps University of Marburg
Andrea Maisner: Institute of Virology, Philipps University of Marburg
Florian Fronhoffs: Institute of Pathology, University of Bonn Medical Centre
Reinhard Buettner: Institute of Pathology, University of Bonn Medical Centre
Elisabeth K. V. Kalko: Institute of Experimental Ecology, University of Ulm
Thomas Kruppa: Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR)
Carlos Roberto Franke: School of Veterinary Medicine, Federal University of Bahia
René Kallies: Institute of Virology, University of Bonn Medical Centre
Emmanuel R.N. Yandoko: Pasteur Institute
Georg Herrler: Institute of Virology, University of Veterinary Medicine Hannover Foundation
Chantal Reusken: Netherlands Center for Infectious Disease Control
Alexandre Hassanin: Muséum National d'Histoire Naturelle/Centre National de la Recherche Scientifique, UMR 7205
Detlev H. Krüger: Institute of Medical Virology (Helmut Ruska Haus), Charité Medical School
Sonja Matthee: Stellenbosch University
Rainer G. Ulrich: Institute for Novel and Emerging Infections Diseases, Friedrich-Loeffler-Institut, Institute for Novel and Emerging Infectious Diseases
Eric M. Leroy: Centre International de Recherches Médicales de Franceville
Christian Drosten: Institute of Virology, University of Bonn Medical Centre

Nature Communications, 2012, vol. 3, issue 1, 1-13

Abstract: Abstract The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data.

Date: 2012
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DOI: 10.1038/ncomms1796

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