Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

Frances P. Noonan, M. Raza Zaidi, Agnieszka Wolnicka-Glubisz, Miriam R. Anver, Jesse Bahn, Albert Wielgus, Jean Cadet, Thierry Douki, Stephane Mouret, Margaret A. Tucker, Anastas Popratiloff, Glenn Merlino and Edward C. De Fabo ()
Additional contact information
Frances P. Noonan: Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University
M. Raza Zaidi: Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
Agnieszka Wolnicka-Glubisz: Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University
Miriam R. Anver: Pathology/Histotechnology Laboratory, SAIC-Frederick, National Cancer Institute-Frederick
Jesse Bahn: Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University
Albert Wielgus: Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park
Jean Cadet: DSM/INAC/SCIB UMR-E 3 CEA/UJF FRE CNRS 3200/Laboratoire 'Lésions des Acides Nucléiques'
Thierry Douki: DSM/INAC/SCIB UMR-E 3 CEA/UJF FRE CNRS 3200/Laboratoire 'Lésions des Acides Nucléiques'
Stephane Mouret: DSM/INAC/SCIB UMR-E 3 CEA/UJF FRE CNRS 3200/Laboratoire 'Lésions des Acides Nucléiques'
Margaret A. Tucker: National Cancer Institute, NIH
Anastas Popratiloff: Center for Microscopy and Image Analysis, Office of the Vice-President, The George Washington University
Glenn Merlino: Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
Edward C. De Fabo: Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University

Nature Communications, 2012, vol. 3, issue 1, 1-10

Abstract: Abstract Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320–400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280–320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis.

Date: 2012
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DOI: 10.1038/ncomms1893

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