Switching of myosin-V motion between the lever-arm swing and Brownian search-and-catch

Keisuke Fujita, Mitsuhiro Iwaki (), Atsuko H. Iwane, Lorenzo Marcucci and Toshio Yanagida ()
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Keisuke Fujita: Soft Biosystem Group, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University
Mitsuhiro Iwaki: Graduate School of Medicine, Osaka University
Atsuko H. Iwane: Soft Biosystem Group, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University
Lorenzo Marcucci: Soft Biosystem Group, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University
Toshio Yanagida: Soft Biosystem Group, Laboratories for Nanobiology, Graduate School of Frontier Biosciences, Osaka University

Nature Communications, 2012, vol. 3, issue 1, 1-9

Abstract: Abstract Motor proteins are force-generating nanomachines that are highly adaptable to their ever-changing biological environments and have a high energy conversion efficiency. Here we constructed an imaging system that uses optical tweezers and a DNA handle to visualize elementary mechanical processes of a nanomachine under load. We apply our system to myosin-V, a well-known motor protein that takes 72 nm 'hand-over-hand' steps composed of a 'lever-arm swing' and a 'Brownian search-and-catch'. We find that the lever-arm swing generates a large proportion of the force at low load (

Date: 2012
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DOI: 10.1038/ncomms1934

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