The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27–CD70 interactions

Sonia Feau, Zacarias Garcia, Ramon Arens, Hideo Yagita, Jannie Borst and Stephen P. Schoenberger ()
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Sonia Feau: Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology
Zacarias Garcia: Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology
Ramon Arens: Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology
Hideo Yagita: Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Jannie Borst: The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Stephen P. Schoenberger: Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology

Nature Communications, 2012, vol. 3, issue 1, 1-9

Abstract: Abstract CD8+ cytotoxic T lymphocytes are critical components of immunity against infectious pathogens, tumours, and in the case of pathogenic autoimmunity, normal self tissues. CD4+ T (TH) cells provide 'help' to CD8+ cytotoxic T lymphocytes during priming by first activating antigen-presenting cells via CD40–CD40L interactions. Here we show that, after immunization with either a noninflammatory, nonreplicating antigen or an overtly inflammatory replicating antigen, CD8+ cytotoxic T lymphocytes prevented from receiving a signal through CD27 during priming subsequently exhibit a specific defect in their capacity for secondary expansion that can be rescued by the absence of TRAIL. Thus, the 'help message' is transmitted to CD8+ T cells via CD70–CD27 signals, enabling them to undergo secondary expansion and avoid TRAIL-mediated apoptosis on re-stimulation. These findings complete our understanding of the cellular interactions through which TH is provided to CD8+ cytotoxic T lymphocytes during priming.

Date: 2012
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DOI: 10.1038/ncomms1948

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