Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

Emily C. McCusker, Claire Bagnéris, Claire E. Naylor, Ambrose R. Cole, Nazzareno D'Avanzo, Colin G. Nichols and B.A. Wallace ()
Additional contact information
Emily C. McCusker: Institute of Structural and Molecular Biology, Birkbeck College, University of London
Claire Bagnéris: Institute of Structural and Molecular Biology, Birkbeck College, University of London
Claire E. Naylor: Institute of Structural and Molecular Biology, Birkbeck College, University of London
Ambrose R. Cole: Institute of Structural and Molecular Biology, Birkbeck College, University of London
Nazzareno D'Avanzo: Excitability Diseases, Washington University School of Medicine
Colin G. Nichols: Excitability Diseases, Washington University School of Medicine
B.A. Wallace: Institute of Structural and Molecular Biology, Birkbeck College, University of London

Nature Communications, 2012, vol. 3, issue 1, 1-8

Abstract: Sodium-gated ion channels open and close in response to the flow of ions. Here, McCusker et al.report the open structure of a sodium-gated ion channel pore from a bacterial homologue, and show, by comparison with the closed structure, that the movement of a C-terminal helix is sufficient to open the channel.

Date: 2012
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms2077 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2077

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms2077

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().