Monosynaptic inputs to new neurons in the dentate gyrus

Carmen Vivar, Michelle C. Potter, Jiwon Choi, Ji-young Lee, Thomas P. Stringer, Edward M. Callaway, Fred H. Gage, Hoonkyo Suh () and Henriette van Praag ()
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Carmen Vivar: Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health
Michelle C. Potter: Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health
Jiwon Choi: Systems Neurobiology Laboratories, The Salk Institute for Biological Studies
Ji-young Lee: Lerner Research Institute, Cleveland Clinic
Thomas P. Stringer: Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health
Edward M. Callaway: Systems Neurobiology Laboratories, The Salk Institute for Biological Studies
Fred H. Gage: Laboratory of Genetics, The Salk Institute for Biological Studies
Hoonkyo Suh: Lerner Research Institute, Cleveland Clinic
Henriette van Praag: Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health

Nature Communications, 2012, vol. 3, issue 1, 1-11

Abstract: Abstract Adult hippocampal neurogenesis is considered important for cognition. The integration of newborn dentate gyrus granule cells into the existing network is regulated by afferent neuronal activity of unspecified origin. Here we combine rabies virus-mediated retrograde tracing with retroviral labelling of new granule cells (21, 30, 60, 90 days after injection) to selectively identify and quantify their monosynaptic inputs in vivo. Our results show that newborn granule cells receive afferents from intra-hippocampal cells (interneurons, mossy cells, area CA3 and transiently, mature granule cells) and septal cholinergic cells. Input from distal cortex (perirhinal (PRH) and lateral entorhinal cortex (LEC)) is sparse 21 days after injection and increases over time. Patch-clamp recordings support innervation by the LEC rather than from the medial entorhinal cortex. Mice with excitotoxic PRH/LEC lesions exhibit deficits in pattern separation but not in water maze learning. Thus, PRH/LEC input is an important functional component of new dentate gyrus neuron circuitry.

Date: 2012
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DOI: 10.1038/ncomms2101

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