A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides

Zhiwei Zhu, Sufang Zhang, Hongwei Liu, Hongwei Shen, Xinping Lin, Fan Yang, Yongjin J. Zhou, Guojie Jin, Mingliang Ye, Hanfa Zou () and Zongbao K. Zhao ()
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Zhiwei Zhu: Dalian Institute of Chemical Physics, CAS
Sufang Zhang: Dalian Institute of Chemical Physics, CAS
Hongwei Liu: Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, CAS
Hongwei Shen: Dalian Institute of Chemical Physics, CAS
Xinping Lin: Dalian Institute of Chemical Physics, CAS
Fan Yang: Dalian Institute of Chemical Physics, CAS
Yongjin J. Zhou: Dalian Institute of Chemical Physics, CAS
Guojie Jin: Dalian Institute of Chemical Physics, CAS
Mingliang Ye: Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, CAS
Hanfa Zou: Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, CAS
Zongbao K. Zhao: Dalian Institute of Chemical Physics, CAS

Nature Communications, 2012, vol. 3, issue 1, 1-12

Abstract: Abstract Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. Here we present the results of a multi-omic analysis of Rhodosporidium toruloides, a robust triacylglycerol-producing fungus. The assembly of genome and transcriptome sequencing data reveals a genome of 20.2 Mb containing 8,171 protein-coding genes, the majority of which have multiple introns. Genes including a novel fatty acid synthase are predicted to participate in metabolic pathways absent in non-oleaginous yeasts. Transcriptomic and proteomic data suggest that lipid accumulation under nitrogen-limited conditions correlates with the induction of lipogenesis, nitrogenous compound recycling, macromolecule metabolism and autophagy. The multi-omic map of R. toruloides therefore provides a valuable resource for efforts to rationally engineer lipid-production pathways.

Date: 2012
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DOI: 10.1038/ncomms2112

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