Identification and characterization of polyclonal αβ-T cells with dendritic cell properties

Mirela Kuka, Ivana Munitic and Jonathan D. Ashwell ()
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Mirela Kuka: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Ivana Munitic: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Jonathan D. Ashwell: Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health

Nature Communications, 2012, vol. 3, issue 1, 1-11

Abstract: Abstract An efficient immune response requires coordination between innate and adaptive immunity, which act through cells different in origin and function. Here we report the identification of thymus-derived αβ-T-cell receptor+ cells that express CD11c and major histocompatibility complex class II, and require FLT3 ligand for development (TDC). TDC express genes heretofore found uniquely in T cells or dendritic cells, as well as a distinctive signature of cytotoxicity-related genes. Unlike other innate T-cell subsets, TDC have a polyclonal T-cell receptor repertoire and respond to cognate antigens. However, they differ from conventional T cells in that they do not require help from antigen-presenting cells, respond to Toll-like receptor-mediated stimulation by producing interleukin-12 and process and present antigen. The physiological relevance of TDC, found in mice and humans, is still under investigation, but the fact that they combine key features of T and dendritic cells suggests that they provide a bridge between the innate and adaptive immune systems.

Date: 2012
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DOI: 10.1038/ncomms2223

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