Synaptic tagging and capture in the living rat

K.L. Shires, B.M. Da Silva, J.P. Hawthorne, R.G.M. Morris and S.J. Martin ()
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K.L. Shires: Centre for Cognitive and Neural Systems (CCNS), University of Edinburgh
B.M. Da Silva: Centre for Cognitive and Neural Systems (CCNS), University of Edinburgh
J.P. Hawthorne: Centre for Cognitive and Neural Systems (CCNS), University of Edinburgh
R.G.M. Morris: Centre for Cognitive and Neural Systems (CCNS), University of Edinburgh
S.J. Martin: Centre for Cognitive and Neural Systems (CCNS), University of Edinburgh

Nature Communications, 2012, vol. 3, issue 1, 1-11

Abstract: Abstract In isolated hippocampal slices, decaying long-term potentiation can be stabilized and converted to late long-term potentiation lasting many hours, by prior or subsequent strong high-frequency tetanization of an independent input to a common population of neurons—a phenomenon known as ‘synaptic tagging and capture’. Here we show that the same phenomenon occurs in the intact rat. Late long-term potentiation can be induced in CA1 during the inhibition of protein synthesis if an independent input is strongly tetanized beforehand. Conversely, declining early long-term potentiation induced by weak tetanization can be converted into lasting late long-term potentiation by subsequent strong tetanization of a separate input. These findings indicate that synaptic tagging and capture is not limited to in vitro preparations; the past and future activity of neurons has a critical role in determining the persistence of synaptic changes in the living animal, thus providing a bridge between cellular studies of protein synthesis-dependent synaptic potentiation and behavioural studies of memory persistence.

Date: 2012
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DOI: 10.1038/ncomms2250

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