Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling

Yuichiro Arima, Sachiko Miyagawa-Tomita, Kazuhiro Maeda, Rieko Asai, Daiki Seya, Maryline Minoux, Filippo M. Rijli, Koichi Nishiyama, Ki-Sung Kim, Yasunobu Uchijima, Hisao Ogawa, Yukiko Kurihara and Hiroki Kurihara ()
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Yuichiro Arima: Graduate School of Medicine, University of Tokyo
Sachiko Miyagawa-Tomita: Medical Research Institute, Tokyo Women’s Medical University
Kazuhiro Maeda: Medical Research Institute, Tokyo Women’s Medical University
Rieko Asai: Graduate School of Medicine, University of Tokyo
Daiki Seya: Graduate School of Medicine, University of Tokyo
Maryline Minoux: Friedrich Miescher Institute for Biomedical Research
Filippo M. Rijli: Friedrich Miescher Institute for Biomedical Research
Koichi Nishiyama: Graduate School of Medicine, University of Tokyo
Ki-Sung Kim: Graduate School of Medicine, University of Tokyo
Yasunobu Uchijima: Graduate School of Medicine, University of Tokyo
Hisao Ogawa: Faculty of Life Sciences, Kumamoto University
Yukiko Kurihara: Graduate School of Medicine, University of Tokyo
Hiroki Kurihara: Graduate School of Medicine, University of Tokyo

Nature Communications, 2012, vol. 3, issue 1, 1-11

Abstract: Abstract Neural crest cells constitute a multipotent cell population that gives rise to diverse cell lineages. The neural crest arising from the postotic hindbrain is known as the ‘cardiac’ neural crest, and contributes to the great vessels and outflow tract endocardial cushions, but the neural crest contribution to structures within the heart remains largely controversial. Here we demonstrate that neural crest cells from the preotic region migrate into the heart and differentiate into coronary artery smooth muscle cells. Preotic neural crest cells preferentially distribute to the conotruncal region and interventricular septum. Ablation of the preotic neural crest causes abnormalities in coronary septal branch and orifice formation. Mice and chicks lacking endothelin signalling show similar abnormalities in the coronary artery, indicating its involvement in neural crest-dependent coronary artery formation. This is the first report that reveals the preotic neural crest contribution to heart development and smooth muscle heterogeneity within a coronary artery.

Date: 2012
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DOI: 10.1038/ncomms2258

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