Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130

Yanlei Ma (), Peng Zhang, Feng Wang, Huizhen Zhang, Yongzhi Yang, Chenzhang Shi, Yang Xia, Jiayuan Peng, Weijie Liu, Zhe Yang and Huanlong Qin ()
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Yanlei Ma: the Tenth People’s Hospital affiliated to Tongji University, 301 Yanchang Road
Peng Zhang: the Tenth People’s Hospital affiliated to Tongji University, 301 Yanchang Road
Feng Wang: the Tenth People’s Hospital affiliated to Tongji University, 301 Yanchang Road
Huizhen Zhang: the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University
Yongzhi Yang: the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University
Chenzhang Shi: the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University
Yang Xia: the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University
Jiayuan Peng: the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University
Weijie Liu: the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University
Zhe Yang: the Sixth People’s Hospital affiliated to Shanghai Jiao Tong University
Huanlong Qin: the Tenth People’s Hospital affiliated to Tongji University, 301 Yanchang Road

Nature Communications, 2012, vol. 3, issue 1, 1-12

Abstract: Abstract MicroRNAs (miRNAs) are essential for regulating normal embryonic development and carcinogenesis. Here we report that miR-17-5p, an oncofoetal miRNA, is a key regulator of colorectal cancer progression. We show that miR-17-5p is an oncogenic miRNA that regulates tumorigenesis and progression by targeting the gene encoding P130 and subsequently activating the Wnt/β-catenin pathway. Using specimens from two large cohorts of colorectal cancer patients, we found that patients whose tumours had high miR-17-5p expression had shorter overall survival rates but showed a better response to adjuvant chemotherapy than did patients whose tumours had low miRNA expression. We also observed a strong inverse correlation between miR-17-5p and P130 expression. The current findings suggest that miR-17-5p is a crucial determinant of colorectal cancer progression.

Date: 2012
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DOI: 10.1038/ncomms2276

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