Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

Ke Tang, Yi Zhang, Huafeng Zhang, Pingwei Xu, Jing Liu, Jingwei Ma, Meng Lv, Dapeng Li, Foad Katirai, Guan-Xin Shen, Guimei Zhang, Zuo-Hua Feng, Duyun Ye and Bo Huang ()
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Ke Tang: Tongji Medical College, Huazhong University of Science and Technology
Yi Zhang: Tongji Medical College, Huazhong University of Science and Technology
Huafeng Zhang: Tongji Medical College, Huazhong University of Science and Technology
Pingwei Xu: Tongji Medical College, Huazhong University of Science and Technology
Jing Liu: Tongji Medical College, Huazhong University of Science and Technology
Jingwei Ma: Tongji Medical College, Huazhong University of Science and Technology
Meng Lv: Tongji Medical College, Huazhong University of Science and Technology
Dapeng Li: Tongji Medical College, Huazhong University of Science and Technology
Foad Katirai: Tongji Medical College, Huazhong University of Science and Technology
Guan-Xin Shen: Tongji Medical College, Huazhong University of Science and Technology
Guimei Zhang: Tongji Medical College, Huazhong University of Science and Technology
Zuo-Hua Feng: Tongji Medical College, Huazhong University of Science and Technology
Duyun Ye: Tongji Medical College, Huazhong University of Science and Technology
Bo Huang: Tongji Medical College, Huazhong University of Science and Technology

Nature Communications, 2012, vol. 3, issue 1, 1-11

Abstract: Abstract Cellular microparticles are vesicular plasma membrane fragments with a diameter of 100–1,000 nanometres that are shed by cells in response to various physiological and artificial stimuli. Here we demonstrate that tumour cell-derived microparticles can be used as vectors to deliver chemotherapeutic drugs. We show that tumour cells incubated with chemotherapeutic drugs package these drugs into microparticles, which can be collected and used to effectively kill tumour cells in murine tumour models without typical side effects. We describe several mechanisms involved in this process, including uptake of drug-containing microparticles by tumour cells, synthesis of additional drug-packaging microparticles by these cells that contribute to the cytotoxic effect and the inhibition of drug efflux from tumour cells. This study highlights a novel drug delivery strategy with potential clinical application.

Date: 2012
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DOI: 10.1038/ncomms2282

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