Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis

Haizhen Wang, Xueliang Gao, Jenny J. Yang and Zhi-Ren Liu ()
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Haizhen Wang: Georgia State University
Xueliang Gao: Georgia State University
Jenny J. Yang: Georgia State University
Zhi-Ren Liu: Georgia State University

Nature Communications, 2013, vol. 4, issue 1, 1-12

Abstract: Abstract p68 RNA helicase is a prototypical RNA helicase. Here we present evidence to show that, by interacting with Ca-calmodulin, p68 has a role in cancer metastasis and cell migration. A peptide fragment that spans the IQ motif of p68 strongly inhibits cancer metastasis in two different animal models. The peptide interrupts p68 and Ca-calmodulin interaction and inhibits cell migration. Our results demonstrate that the p68–Ca-calmodulin interaction is essential for the formation of lamellipodia and filopodia in migrating cells. p68 interacts with microtubules in the presence of Ca-calmodulin. Our experiments show that interaction with microtubules stimulates p68 ATPase activity. Further, microtubule gliding assays demonstrate that p68, in the presence of Ca-calmodulin, can function as a microtubule motor. This motor activity may allow p68 to transport Ca-calmodulin to the leading edge of migrating cells.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2345

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DOI: 10.1038/ncomms2345

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