On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

Esther Krook-Magnuson (), Caren Armstrong, Mikko Oijala and Ivan Soltesz
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Esther Krook-Magnuson: University of California
Caren Armstrong: University of California
Mikko Oijala: University of California
Ivan Soltesz: University of California

Nature Communications, 2013, vol. 4, issue 1, 1-8

Abstract: Abstract Temporal lobe epilepsy is the most common type of epilepsy in adults, is often medically refractory, and due to broad actions and long-time scales, current systemic treatments have major negative side-effects. However, temporal lobe seizures tend to arise from discrete regions before overt clinical behaviour, making temporally and spatially specific treatment theoretically possible. Here we report the arrest of spontaneous seizures using a real-time, closed-loop, response system and in vivo optogenetics in a mouse model of temporal lobe epilepsy. Either optogenetic inhibition of excitatory principal cells, or activation of a subpopulation of GABAergic cells representing

Date: 2013
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DOI: 10.1038/ncomms2376

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