Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain

Fabian Fischer, Andrea Weil, Andrea Hamann and Heinz D. Osiewacz ()
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Fabian Fischer: Johann Wolfgang Goethe University, Faculty for Biosciences & Cluster of Excellence, ‘Macromolecular Complexes’ Frankfurt, Institute of Molecular Biosciences
Andrea Weil: Johann Wolfgang Goethe University, Faculty for Biosciences & Cluster of Excellence, ‘Macromolecular Complexes’ Frankfurt, Institute of Molecular Biosciences
Andrea Hamann: Johann Wolfgang Goethe University, Faculty for Biosciences & Cluster of Excellence, ‘Macromolecular Complexes’ Frankfurt, Institute of Molecular Biosciences
Heinz D. Osiewacz: Johann Wolfgang Goethe University, Faculty for Biosciences & Cluster of Excellence, ‘Macromolecular Complexes’ Frankfurt, Institute of Molecular Biosciences

Nature Communications, 2013, vol. 4, issue 1, 1-6

Abstract: Abstract Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondrial matrix. Here we show that deletion of PaClpP, encoding the CLP protease proteolytic subunit CLPP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina. This phenotype can be reverted by expression of human ClpP in the fungal deletion background, demonstrating functional conservation of human and fungal CLPP. Our results show that the biological role of eukaryotic CLP proteases can be studied in an experimentally accessible model organism.

Date: 2013
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DOI: 10.1038/ncomms2397

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