In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels

Hidekazu Sekine, Tatsuya Shimizu, Katsuhisa Sakaguchi, Izumi Dobashi, Masanori Wada, Masayuki Yamato, Eiji Kobayashi, Mitsuo Umezu and Teruo Okano ()
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Hidekazu Sekine: Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns
Tatsuya Shimizu: Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns
Katsuhisa Sakaguchi: Faculty of Science and Engineering, Waseda University, TWIns
Izumi Dobashi: Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns
Masanori Wada: ABLE Corporation
Masayuki Yamato: Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns
Eiji Kobayashi: Center for Development of Advanced Medical Technology, Jichi Medical University
Mitsuo Umezu: Faculty of Science and Engineering, Waseda University, TWIns
Teruo Okano: Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, TWIns

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Artificially engineered tissues may have many therapeutic applications but complex tissues are hard to create in vitro. Here, Okano and colleagues report the production of functional cardiac tissue sheets with perfusable blood vessels, which increase the thickness and survival of transplanted tissue.

Date: 2013
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DOI: 10.1038/ncomms2406

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