Genome of the Chinese tree shrew

Yu Fan, Zhi-Yong Huang, Chang-Chang Cao, Ce-Shi Chen, Yuan-Xin Chen, Ding-Ding Fan, Jing He, Hao-Long Hou, Li Hu, Xin-Tian Hu, Xuan-Ting Jiang, Ren Lai, Yong-Shan Lang, Bin Liang, Sheng-Guang Liao, Dan Mu, Yuan-Ye Ma, Yu-Yu Niu, Xiao-Qing Sun, Jin-Quan Xia, Jin Xiao, Zhi-Qiang Xiong, Lin Xu, Lan Yang, Yun Zhang, Wei Zhao, Xu-Dong Zhao, Yong-Tang Zheng, Ju-Min Zhou, Ya-Bing Zhu, Guo-Jie Zhang (), Jun Wang () and Yong-Gang Yao ()
Additional contact information
Yu Fan: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Zhi-Yong Huang: BGI-Shenzhen
Chang-Chang Cao: BGI-Shenzhen
Ce-Shi Chen: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Yuan-Xin Chen: BGI-Shenzhen
Ding-Ding Fan: BGI-Shenzhen
Jing He: BGI-Shenzhen
Hao-Long Hou: BGI-Shenzhen
Li Hu: BGI-Shenzhen
Xin-Tian Hu: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Xuan-Ting Jiang: BGI-Shenzhen
Ren Lai: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Yong-Shan Lang: BGI-Shenzhen
Bin Liang: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Sheng-Guang Liao: BGI-Shenzhen
Dan Mu: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Yuan-Ye Ma: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Yu-Yu Niu: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Xiao-Qing Sun: BGI-Shenzhen
Jin-Quan Xia: BGI-Shenzhen
Jin Xiao: BGI-Shenzhen
Zhi-Qiang Xiong: BGI-Shenzhen
Lin Xu: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Lan Yang: BGI-Shenzhen
Yun Zhang: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Wei Zhao: BGI-Shenzhen
Xu-Dong Zhao: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Yong-Tang Zheng: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Ju-Min Zhou: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Ya-Bing Zhu: BGI-Shenzhen
Guo-Jie Zhang: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming
Jun Wang: BGI-Shenzhen
Yong-Gang Yao: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming

Nature Communications, 2013, vol. 4, issue 1, 1-9

Abstract: Abstract Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as models for a variety of human disorders: depression, myopia, hepatitis B and C virus infections, and hepatocellular carcinoma, to name a few. Here we present a publicly available annotated genome sequence for the Chinese tree shrew. Phylogenomic analysis of the tree shrew and other mammalians highly support its close affinity to primates. By characterizing key factors and signalling pathways in nervous and immune systems, we demonstrate that tree shrews possess both shared common and unique features, and provide a genetic basis for the use of this animal as a potential model for biomedical research.

Date: 2013
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DOI: 10.1038/ncomms2416

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