Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals

Yong-Hong Zhang, Yan Zhao, Ning Li, Yan-Chun Peng, Eleni Giannoulatou, Rong-Hua Jin, Hui-Ping Yan, Hao Wu, Jin-Hua Liu, Ning Liu, Da-Yan Wang, Yue-Long Shu, Ling-Pei Ho, Paul Kellam, Andrew McMichael and Tao Dong ()
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Yong-Hong Zhang: Beijing You'an Hospital, Capital Medical University
Yan Zhao: Beijing You'an Hospital, Capital Medical University
Ning Li: Beijing You'an Hospital, Capital Medical University
Yan-Chun Peng: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University
Eleni Giannoulatou: The Computational Biology Research Group, Weatherall Institute for Molecular Medicine, Oxford University
Rong-Hua Jin: Beijing You'an Hospital, Capital Medical University
Hui-Ping Yan: Beijing You'an Hospital, Capital Medical University
Hao Wu: Beijing You'an Hospital, Capital Medical University
Jin-Hua Liu: Beijing You'an Hospital, Capital Medical University
Ning Liu: Beijing You'an Hospital, Capital Medical University
Da-Yan Wang: Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC
Yue-Long Shu: Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC
Ling-Pei Ho: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University
Paul Kellam: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Andrew McMichael: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University
Tao Dong: Beijing You'an Hospital, Capital Medical University

Nature Communications, 2013, vol. 4, issue 1, 1-6

Abstract: Abstract The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.

Date: 2013
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DOI: 10.1038/ncomms2433

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