Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival

Lisheng Peng, Huisheng Liu, Hongyu Ruan, William H. Tepp, William H. Stoothoff, Robert H. Brown, Eric A. Johnson, Wei-Dong Yao, Su-Chun Zhang and Min Dong ()
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Lisheng Peng: Harvard Medical School, New England Primate Research Center
Huisheng Liu: University of Wisconsin, Waisman Center and the WiCell Institute
Hongyu Ruan: Harvard Medical School, New England Primate Research Center
William H. Tepp: University of Wisconsin
William H. Stoothoff: University of Massachusetts Medical School
Robert H. Brown: University of Massachusetts Medical School
Eric A. Johnson: University of Wisconsin
Wei-Dong Yao: Harvard Medical School, New England Primate Research Center
Su-Chun Zhang: University of Wisconsin, Waisman Center and the WiCell Institute
Min Dong: Harvard Medical School, New England Primate Research Center

Nature Communications, 2013, vol. 4, issue 1, 1-12

Abstract: Botulinum toxins can cause substantial neurodegeneration. Peng et al. study cultured rat hippocampal neurons and find that botulinum toxin-induced cytotoxicity occurs only when there is effective cleavage of the SNARE proteins, syntaxin 1 or SNAP-25, by type C and type E botulinum toxins.

Date: 2013
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DOI: 10.1038/ncomms2462

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