Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease

Ines Moreno-Gonzalez, Lisbell D. Estrada, Elisabeth Sanchez-Mejias and Claudio Soto ()
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Ines Moreno-Gonzalez: Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, University of Texas Medical School at Houston
Lisbell D. Estrada: Laboratorio Señalización Celular, P Universidad Católica de Chile, Santiago, Chile and Universidad Bernando O’Higgins
Elisabeth Sanchez-Mejias: University of Malaga, CIBERNED
Claudio Soto: Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, University of Texas Medical School at Houston

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer’s disease. However, inconsistent results have been reported regarding the risk of Alzheimer’s disease among smokers. Previous studies in experimental animal models have reported that administration of some cigarette components (for example, nicotine) alters amyloid-β aggregation, providing a possible link. However, extrapolation of these findings towards the in vivo scenario is not straightforward as smoke inhalation involves a number of other components. Here, we analysed the effect of smoking under more relevant conditions. We exposed transgenic mouse models of Alzheimer’s disease to cigarette smoke and analysed the neuropathological alterations in comparison with animals not subjected to smoke inhalation. Our results showed that smoking increases the severity of some abnormalities typical of Alzheimer’s disease, including amyloidogenesis, neuroinflammation and tau phosphorylation. Our findings suggest that cigarette smoking may increase Alzheimer’s disease onset and exacerbate its features and thus, may constitute an important environmental risk factor for Alzheimer’s disease.

Date: 2013
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DOI: 10.1038/ncomms2494

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