Holographic optogenetic stimulation of patterned neuronal activity for vision restoration

Inna Reutsky-Gefen, Lior Golan, Nairouz Farah, Adi Schejter, Limor Tsur, Inbar Brosh and Shy Shoham ()
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Inna Reutsky-Gefen: Faculty of Biomedical Engineering, Technion—Israel Institute of Technology
Lior Golan: Faculty of Biomedical Engineering, Technion—Israel Institute of Technology
Nairouz Farah: Faculty of Biomedical Engineering, Technion—Israel Institute of Technology
Adi Schejter: Faculty of Biomedical Engineering, Technion—Israel Institute of Technology
Limor Tsur: Faculty of Biomedical Engineering, Technion—Israel Institute of Technology
Inbar Brosh: Faculty of Biomedical Engineering, Technion—Israel Institute of Technology
Shy Shoham: Faculty of Biomedical Engineering, Technion—Israel Institute of Technology

Nature Communications, 2013, vol. 4, issue 1, 1-9

Abstract: Abstract When natural photoreception is disrupted, as in outer-retinal degenerative diseases, artificial stimulation of surviving nerve cells offers a potential strategy for bypassing compromised neural circuits. Recently, light-sensitive proteins that photosensitize quiescent neurons have generated unprecedented opportunities for optogenetic neuronal control, inspiring early development of optical retinal prostheses. Selectively exciting large neural populations are essential for eliciting meaningful perceptions in the brain. Here we provide the first demonstration of holographic photo-stimulation strategies for bionic vision restoration. In blind retinas, we demonstrate reliable holographically patterned optogenetic stimulation of retinal ganglion cells with millisecond temporal precision and cellular resolution. Holographic excitation strategies could enable flexible control over distributed neuronal circuits, potentially paving the way towards high-acuity vision restoration devices and additional medical and scientific neuro-photonics applications.

Date: 2013
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DOI: 10.1038/ncomms2500

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