Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels

Lucian Medrihan (), Fabrizia Cesca, Andrea Raimondi, Gabriele Lignani, Pietro Baldelli and Fabio Benfenati
Additional contact information
Lucian Medrihan: Istituto Italiano di Tecnologia, Via Morego 30
Fabrizia Cesca: Istituto Italiano di Tecnologia, Via Morego 30
Andrea Raimondi: Istituto Italiano di Tecnologia, Via Morego 30
Gabriele Lignani: Istituto Italiano di Tecnologia, Via Morego 30
Pietro Baldelli: Istituto Italiano di Tecnologia, Via Morego 30
Fabio Benfenati: Istituto Italiano di Tecnologia, Via Morego 30

Nature Communications, 2013, vol. 4, issue 1, 1-13

Abstract: Abstract In the central nervous system, most synapses show a fast mode of neurotransmitter release known as synchronous release followed by a phase of asynchronous release, which extends over tens of milliseconds to seconds. Synapsin II (SYN2) is a member of the multigene synapsin family (SYN1/2/3) of synaptic vesicle phosphoproteins that modulate synaptic transmission and plasticity, and are mutated in epileptic patients. Here we report that inhibitory synapses of the dentate gyrus of Syn II knockout mice display an upregulation of synchronous neurotransmitter release and a concomitant loss of delayed asynchronous release. Syn II promotes γ-aminobutyric acid asynchronous release in a Ca2+-dependent manner by a functional interaction with presynaptic Ca2+ channels, revealing a new role in synaptic transmission for synapsins.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms2515 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2515

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms2515

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().