A synthetic nanomaterial for virus recognition produced by surface imprinting

Alessandro Cumbo, Bernard Lorber, Philippe F.-X. Corvini, Wolfgang Meier and Patrick Shahgaldian ()
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Alessandro Cumbo: School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland
Bernard Lorber: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, UPR9002
Philippe F.-X. Corvini: School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland
Wolfgang Meier: University of Basel
Patrick Shahgaldian: School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract Major stumbling blocks in the production of fully synthetic materials designed to feature virus recognition properties are that the target is large and its self-assembled architecture is fragile. Here we describe a synthetic strategy to produce organic/inorganic nanoparticulate hybrids that recognize non-enveloped icosahedral viruses in water at concentrations down to the picomolar range. We demonstrate that these systems bind a virus that, in turn, acts as a template during the nanomaterial synthesis. These virus imprinted particles then display remarkable selectivity and affinity. The reported method, which is based on surface imprinting using silica nanoparticles that act as a carrier material and organosilanes serving as biomimetic building blocks, goes beyond simple shape imprinting. We demonstrate the formation of a chemical imprint, comparable to the formation of biosilica, due to the template effect of the virion surface on the synthesis of the recognition material.

Date: 2013
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DOI: 10.1038/ncomms2529

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