In vivo recordings of brain activity using organic transistors

Dion Khodagholy, Thomas Doublet, Pascale Quilichini, Moshe Gurfinkel, Pierre Leleux, Antoine Ghestem, Esma Ismailova, Thierry Hervé, Sébastien Sanaur, Christophe Bernard () and George G. Malliaras ()
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Dion Khodagholy: Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC
Thomas Doublet: Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC
Pascale Quilichini: Aix Marseille Université, INS
Moshe Gurfinkel: Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC
Pierre Leleux: Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC
Antoine Ghestem: Aix Marseille Université, INS
Esma Ismailova: Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC
Thierry Hervé: Microvitae Technologies, Pôle d’Activité Y. Morandat
Sébastien Sanaur: Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC
Christophe Bernard: Aix Marseille Université, INS
George G. Malliaras: Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC

Nature Communications, 2013, vol. 4, issue 1, 1-7

Abstract: Abstract In vivo electrophysiological recordings of neuronal circuits are necessary for diagnostic purposes and for brain-machine interfaces. Organic electronic devices constitute a promising candidate because of their mechanical flexibility and biocompatibility. Here we demonstrate the engineering of an organic electrochemical transistor embedded in an ultrathin organic film designed to record electrophysiological signals on the surface of the brain. The device, tested in vivo on epileptiform discharges, displayed superior signal-to-noise ratio due to local amplification compared with surface electrodes. The organic transistor was able to record on the surface low-amplitude brain activities, which were poorly resolved with surface electrodes. This study introduces a new class of biocompatible, highly flexible devices for recording brain activity with superior signal-to-noise ratio that hold great promise for medical applications.

Date: 2013
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DOI: 10.1038/ncomms2573

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