The transcriptional repressor NKAP is required for the development of iNKT cells

Puspa Thapa, Joy Das, Douglas McWilliams, Michael Shapiro, Rhianna Sundsbak, Molly Nelson-Holte, Sarah Tangen, Joshua Anderson, Stephen Desiderio, Scott Hiebert, Derek B. Sant’Angelo and Virginia Smith Shapiro ()
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Puspa Thapa: Mayo Clinic
Joy Das: Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School
Douglas McWilliams: Mayo Clinic
Michael Shapiro: Mayo Clinic
Rhianna Sundsbak: Mayo Clinic
Molly Nelson-Holte: Mayo Clinic
Sarah Tangen: Mayo Clinic
Joshua Anderson: Mayo Clinic
Stephen Desiderio: and Institute for Cell Engineering, The Johns Hopkins University School of Medicine
Scott Hiebert: Vanderbilt University School of Medicine, 512 Preston Research Building, Nashville, Tennessee 37232, USA
Derek B. Sant’Angelo: Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School
Virginia Smith Shapiro: Mayo Clinic

Nature Communications, 2013, vol. 4, issue 1, 1-11

Abstract: Abstract Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T cell development is blocked at the double-positive stage. This cell-intrinsic block is not due to decreased survival or failure to rearrange the invariant Vα14-Jα18 T cell receptor-α chain, but is rescued by overexpression of a rec-Vα14-Jα18 transgene at the double-positive stage, thus defining a role for NKAP in selection into the invariant natural killer T cell lineage. Importantly, deletion of the NKAP-associated protein histone deacetylase 3 causes a similar block in the invariant natural killer T cell development, indicating that NKAP and histone deacetylase 3 functionally interact to control invariant natural killer T cell development.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2580

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DOI: 10.1038/ncomms2580

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