Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours

Hye-ri Sim, Tae-Yong Choi, Hyo Jin Lee, Eun Young Kang, Sehyoun Yoon, Pyung-Lim Han, Se-Young Choi () and Ja-Hyun Baik ()
Additional contact information
Hye-ri Sim: Molecular Neurobiology Laboratory, School of Life Sciences and Biotechnology, Korea University
Tae-Yong Choi: Seoul National University School of Dentistry
Hyo Jin Lee: Molecular Neurobiology Laboratory, School of Life Sciences and Biotechnology, Korea University
Eun Young Kang: Molecular Neurobiology Laboratory, School of Life Sciences and Biotechnology, Korea University
Sehyoun Yoon: Molecular Neurobiology Laboratory, School of Life Sciences and Biotechnology, Korea University
Pyung-Lim Han: Ewha Womans University
Se-Young Choi: Seoul National University School of Dentistry
Ja-Hyun Baik: Molecular Neurobiology Laboratory, School of Life Sciences and Biotechnology, Korea University

Nature Communications, 2013, vol. 4, issue 1, 1-11

Abstract: Abstract Dopaminergic systems are implicated in stress-related behaviour. Here we investigate behavioural responses to chronic stress in dopamine D2 receptor knockout mice and find that anxiety-like behaviours are increased compared with wild-type mice. Repeated stress exposure suppresses cocaine-induced behavioural sensitization, cocaine-seeking and relapse behaviours in dopamine D2 receptor knockout mice. Cocaine challenge after drug withdrawal in cocaine-experienced wild-type or dopamine D2 receptor knockout mice is associated with inhibition of long-term depression in the nucleus accumbens, and chronic stress during withdrawal prevents inhibition after cocaine challenge in cocaine-experienced dopamine D2 receptor knockout mice, but not in wild-type mice. Lentiviral-induced knockdown of dopamine D2 receptors in the nucleus accumbens of wild-type mice does not affect basal locomotor activity, but confers stress-induced inhibition of the expression of cocaine-induced behavioural sensitization. Stressed mice depleted of dopamine D2 receptors do not manifest long-term depression inhibition. Our results suggest that dopamine D2 receptors have roles in regulating synaptic modification triggered by stress and drug addiction.

Date: 2013
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms2598 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2598

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms2598

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().