Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees

Mary J. Palmer, Christopher Moffat, Nastja Saranzewa, Jenni Harvey, Geraldine A. Wright and Christopher N. Connolly ()
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Mary J. Palmer: Medical Research Institute, Ninewells Medical School, University of Dundee
Christopher Moffat: Medical Research Institute, Ninewells Medical School, University of Dundee
Nastja Saranzewa: Medical Research Institute, Ninewells Medical School, University of Dundee
Jenni Harvey: Medical Research Institute, Ninewells Medical School, University of Dundee
Geraldine A. Wright: Centre for Behaviour and Evolution, Institute of Neuroscience, Newcastle University
Christopher N. Connolly: Medical Research Institute, Ninewells Medical School, University of Dundee

Nature Communications, 2013, vol. 4, issue 1, 1-8

Abstract: Abstract Pesticides that target cholinergic neurotransmission are highly effective, but their use has been implicated in insect pollinator population decline. Honeybees are exposed to two widely used classes of cholinergic pesticide: neonicotinoids (nicotinic receptor agonists) and organophosphate miticides (acetylcholinesterase inhibitors). Although sublethal levels of neonicotinoids are known to disrupt honeybee learning and behaviour, the neurophysiological basis of these effects has not been shown. Here, using recordings from mushroom body Kenyon cells in acutely isolated honeybee brain, we show that the neonicotinoids imidacloprid and clothianidin, and the organophosphate miticide coumaphos oxon, cause a depolarization-block of neuronal firing and inhibit nicotinic responses. These effects are observed at concentrations that are encountered by foraging honeybees and within the hive, and are additive with combined application. Our findings demonstrate a neuronal mechanism that may account for the cognitive impairments caused by neonicotinoids, and predict that exposure to multiple pesticides that target cholinergic signalling will cause enhanced toxicity to pollinators.

Date: 2013
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DOI: 10.1038/ncomms2648

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