Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Paul Brotherton (), Wolfgang Haak (), Jennifer Templeton, Guido Brandt, Julien Soubrier, Christina Jane Adler, Stephen M. Richards, Clio Der Sarkissian, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Mannis van Oven, Rosalie Kenyon, Mark B. Van der Hoek, Jonas Korlach, Khai Luong, Simon Y.W. Ho, Lluis Quintana-Murci, Doron M. Behar, Harald Meller, Kurt W. Alt and Alan Cooper
Additional contact information
Paul Brotherton: The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
Wolfgang Haak: The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
Jennifer Templeton: The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
Guido Brandt: Institute of Anthropology, Colonel-Kleinmann Weg 2, Johannes Gutenberg University Mainz
Julien Soubrier: The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
Christina Jane Adler: The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
Stephen M. Richards: The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
Clio Der Sarkissian: The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
Robert Ganslmeier: State Office for Heritage Management and Archaeology Saxony-Anhalt/State Museum for Prehistory Halle
Susanne Friederich: State Office for Heritage Management and Archaeology Saxony-Anhalt/State Museum for Prehistory Halle
Veit Dresely: State Office for Heritage Management and Archaeology Saxony-Anhalt/State Museum for Prehistory Halle
Mannis van Oven: Erasmus MC, University Medical Centre Rotterdam
Rosalie Kenyon: SA Pathology, SA Health
Mark B. Van der Hoek: SA Pathology, SA Health
Jonas Korlach: Pacific Biosciences
Khai Luong: Pacific Biosciences
Simon Y.W. Ho: School of Biological Sciences, The University of Sydney
Lluis Quintana-Murci: Institut Pasteur, Unit of Evolutionary Genetics
Doron M. Behar: Rambam Medical Centre
Harald Meller: State Office for Heritage Management and Archaeology Saxony-Anhalt/State Museum for Prehistory Halle
Kurt W. Alt: Institute of Anthropology, Colonel-Kleinmann Weg 2, Johannes Gutenberg University Mainz
Alan Cooper: The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide

Nature Communications, 2013, vol. 4, issue 1, 1-11

Abstract: Abstract Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this ‘real-time’ genetic data with cultural changes taking place between the Early Neolithic (~5450 BC) and Bronze Age (~2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (~4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (~2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

Date: 2013
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms2656 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2656

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms2656

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().