A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue

Seung Yun Yang, Eoin D. O'Cearbhaill, Geoffroy C Sisk, Kyeng Min Park, Woo Kyung Cho, Martin Villiger, Brett E. Bouma, Bohdan Pomahac and Jeffrey M. Karp ()
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Seung Yun Yang: Brigham and Women’s Hospital, Harvard Medical School
Eoin D. O'Cearbhaill: Brigham and Women’s Hospital, Harvard Medical School
Geoffroy C Sisk: Brigham and Women’s Hospital, 75 Francis Street
Kyeng Min Park: Harvard University
Woo Kyung Cho: Brigham and Women’s Hospital, Harvard Medical School
Martin Villiger: Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 40 Blossom Street
Brett E. Bouma: Massachusetts Institute of Technology
Bohdan Pomahac: Brigham and Women’s Hospital, 75 Francis Street
Jeffrey M. Karp: Brigham and Women’s Hospital, Harvard Medical School

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant inflammatory response. Staples are fraught with limitations including high-localized tissue stress and increased risk of infection, and nerve and blood vessel damage. Here inspired by the endoparasite Pomphorhynchus laevis, which swells its proboscis to attach to its host’s intestinal wall, we have developed a biphasic microneedle array that mechanically interlocks with tissue through swellable microneedle tips, achieving ~3.5-fold increase in adhesion strength compared with staples in skin graft fixation, and removal force of ~4.5 N cm−2 from intestinal mucosal tissue. Comprising a poly(styrene)-block-poly(acrylic acid) swellable tip and non-swellable polystyrene core, conical microneedles penetrate tissue with minimal insertion force and depth, yet high adhesion strength in their swollen state. Uniquely, this design provides universal soft tissue adhesion with minimal damage, less traumatic removal, reduced risk of infection and delivery of bioactive therapeutics.

Date: 2013
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DOI: 10.1038/ncomms2715

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