Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice

Jun Kunisawa (), Masashi Gohda, Eri Hashimoto, Izumi Ishikawa, Morio Higuchi, Yuji Suzuki, Yoshiyuki Goto, Casandra Panea, Ivaylo I. Ivanov, Risa Sumiya, Lamichhane Aayam, Taichi Wake, So Tajiri, Yosuke Kurashima, Shiori Shikata, Shizuo Akira, Kiyoshi Takeda and Hiroshi Kiyono
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Jun Kunisawa: The Institute of Medical Science, The University of Tokyo
Masashi Gohda: The Institute of Medical Science, The University of Tokyo
Eri Hashimoto: The Institute of Medical Science, The University of Tokyo
Izumi Ishikawa: The Institute of Medical Science, The University of Tokyo
Morio Higuchi: The Institute of Medical Science, The University of Tokyo
Yuji Suzuki: The Institute of Medical Science, The University of Tokyo
Yoshiyuki Goto: The Institute of Medical Science, The University of Tokyo
Casandra Panea: Columbia University Medical Center
Ivaylo I. Ivanov: Columbia University Medical Center
Risa Sumiya: The Institute of Medical Science, The University of Tokyo
Lamichhane Aayam: The Institute of Medical Science, The University of Tokyo
Taichi Wake: The Institute of Medical Science, The University of Tokyo
So Tajiri: The Institute of Medical Science, The University of Tokyo
Yosuke Kurashima: The Institute of Medical Science, The University of Tokyo
Shiori Shikata: The Institute of Medical Science, The University of Tokyo
Shizuo Akira: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University
Kiyoshi Takeda: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency
Hiroshi Kiyono: The Institute of Medical Science, The University of Tokyo

Nature Communications, 2013, vol. 4, issue 1, 1-10

Abstract: Abstract Intestinal plasma cells predominantly produce immunoglobulin (Ig) A, however, their functional diversity remains poorly characterized. Here we show that murine intestinal IgA plasma cells can be newly classified into two populations on the basis of CD11b expression, which cannot be discriminated by currently known criteria such as general plasma cell markers, B cell origin and T cell dependence. CD11b+ IgA+ plasma cells require the lymphoid structure of Peyer’s patches, produce more IgA than CD11b− IgA+ plasma cells, proliferate vigorously, and require microbial stimulation and IL-10 for their development and maintenance. These features allow CD11b+ IgA+ plasma cells to mediate early-phase antigen-specific intestinal IgA responses induced by oral immunization with protein antigen. These findings reveal the functional diversity of IgA+ plasma cells in the murine intestine.

Date: 2013
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DOI: 10.1038/ncomms2718

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